Lipid‐DNAs as Solubilizers of mTHPC

نویسندگان

  • Yun Liu
  • Jan Willem de Vries
  • Qing Liu
  • Alwin M Hartman
  • Gerhard D Wieland
  • Sebastian Wieczorek
  • Hans G Börner
  • Arno Wiehe
  • Eric Buhler
  • Marc C A Stuart
  • Wesley R Browne
  • Andreas Herrmann
  • Anna K H Hirsch
چکیده

Hydrophobic drug candidates require innovative formulation agents. We designed and synthesized lipid-DNA polymers containing varying numbers of hydrophobic alkyl chains. The hydrophobicity of these amphiphiles is easily tunable by introducing a defined number of alkyl chain-modified nucleotides during standard solid-phase synthesis of DNA using an automated DNA synthesizer. We observed that the resulting self-assembled micelles solubilize the poorly water-soluble drug, meta-tetra-hydroxyphenyl-chlorin (mTHPC) used in photodynamic therapy (PDT) with high loading concentrations and loading capacities. A cell viability study showed that mTHPC-loaded micelles exhibit good biocompatibility without irradiation, and high PDT efficacy upon irradiation. Lipid-DNAs provide a novel class of drug-delivery vehicle, and hybridization of DNA offers a potentially facile route for further functionalization of the drug-delivery system with, for instance, targeting or imaging moieties.

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عنوان ژورنال:

دوره 24  شماره 

صفحات  -

تاریخ انتشار 2018